The short-term limit for total inhalable dust is 20 mg/m3. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM An agricultural sciences company. It is . Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Some substance identifiers may have been claimed confidential, or may . Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. ( JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . We are artists at heart and creators by nature. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. EINECS #: 232-674-9 1.7. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Material safety data sheet - FMC Corporation. % MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Medium size standard MCC grade, suited for the majority of directly compressible actives. Eur., JPE . Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Report Category. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. However, if handling bulk powders, observance of appropriate safeguards is recommended. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Gloves, eye protection and a dust mask should be used. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. : 160182. P}MFbN#[>r(y FIRST AID MEASURES Eye Contact Hold eyes open and rinse slowly and gently with water for 15 to 20 minutes. } !1AQa"q2#BR$3br Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. CAS #: 9004-34-6 PDF (2.77 mb) 2021 FMC Sustainability Report. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . Production of Pharmaceutical Grade Microcrystalline Cellulose. Biologicals by FMC. <> Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. w !1AQaq"2B #3Rbr SDS - Safety Data Sheet. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? 4 0 obj (1962). "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. Page 1 of 8. MSDS Ref. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz CAS #: 9004-34-6 . Are you looking for information about products and services by region? CAS 9004-34-6. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. : 160182 Date Approved: 05/25/2010 Revision No. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Created Date: 2/10/2020 8:51:41 PM . A family of polysaccharide products that allow distinctive drug delivery solutions. endobj The charts below provide guidance on how to select and use standard and co-processed grades of Avicel Microcrystalline cellulose in pharmaceutical products. (Microcrystalline Cellulose Market Pr. Trademarks: Avicel PH-102. Watch Now. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. %PDF-1.5 Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. 1. It works as a moisture sponge and permits the controlled growth of spheroids. %PDF-1.4 However, consumption of large quantities of the material may have a laxative effect. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Product Name: Microcrystalline Cellulose E460 1.2. FMC Corporation. : CL-611NF Date Approved: 01/13/2010. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. <> In extrusion-spheronisation, it is the excipient of choice. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> ( FMC, JRS and Mingtai were estimated to hold for . CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. endobj pH 6.0 to 8.0 . Doses up to 30 g per day appear to be . Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. <> MATERIAL SAFETY DATA SHEET. It is also inert and biocompatible. Chemical Formula: (C6H10O5)n 1.4. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. Microcrystalline Cellulose; Cellulose; Functions. Avicel PC 611 (FMC Biopolymer) . Quick Links. No. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Chemical Formula: (C6H10O5)n 1.4. Learn about our new global sustainability platform, Learn about FMC's industry leading goal of net-zero emissions by 2035, Learn about FMC's differentiated biologically-based crop solutions. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. 0.25 - 0.37. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Safety Data Sheet for Cellulose microcrystalline 102331. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. 6 0 obj Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . : 9004-34-6 Date Approved: 01/31/2008 . . YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& : 51395-75-6 Date Approved: 01/31/2008 Revision No. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 2021 Annual Report. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Synonyms: Cellulose, Cellulose powder, Cotton linters. Test Data Available. cas:9000-11-7 msds Carboxymethyl cellulose. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Explore how we work and why we apply science and creativity for a better world to everything we do. Catalog Number 102331. Battista, O. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. << The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. BIOACCUMULATIVE POTENTIAL SUBSTANCE IDENTIFICATION 1.1. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Microcrystalline Cellulose / Avicel PH-102. This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. Home. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Aqueous suspensions of microcrystalline cellulose have . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Go to Investor Relations. These grades have particle sizes ranging from <30 to approximately 200. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. 102331. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication << Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . << ( }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge on Avicel microcrystalline cellulose, the most trusted excipient brand for decades.
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microcrystalline cellulose msds fmc